Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease
نویسندگان
چکیده
منابع مشابه
Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier
The blood-brain barrier (BBB) is essential for maintaining brain homeostasis and protecting neural tissue from damaging blood-borne agents. The barrier is characterized by endothelial tight junctions that limit passive paracellular diffusion of polar solutes and macromolecules from blood to brain. Decreased brain clearance of the neurotoxic amyloid-β (Aβ) peptide is a central event in the patho...
متن کاملAutoregulated paracellular clearance of amyloid-b across the blood-brain barrier
Smurfit Institute of Genetics, Lincoln Place Gate, Trinity College Dublin, Dublin 2, Ireland. Laboratory for Neurodegenerative Research, Center for Neurological Diseases, Brigham and Women’s Hospital, Harvard Institute of Medicine, 77 Avenue Louis Pasteur, Boston, MA 02115, USA. Department of Neuropathology, Beaumont Hospital, Dublin 9, Ireland. UCD School of Veterinary Medicine and Conway Inst...
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Accumulation of amyloid beta-peptide (Abeta) in the central nervous system (CNS) may initiate pathogenic cascades mediating neurovascular and neuronal dysfunctions associated with the development of cerebral beta-amyloidosis and cognitive decline in patients with Alzheimer disease (AD) and with related familial cerebrovascular disorders. Whether Abeta-related pathology in the CNS is reversible ...
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Accumulation of amyloid -peptide (A ) in the central nervous system (CNS) may initiate pathogenic cascades mediating neurovascular and neuronal dysfunctions associated with the development of cerebral -amyloidosis and cognitive decline in patients with Alzheimer disease (AD) and with related familial cerebrovascular disorders. Whether A -related pathology in the CNS is reversible or not and wha...
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Rashid Deane,1* Abhay Sagare,1* Katie Hamm,1 Margaret Parisi,1 Barbra LaRue,1 Huang Guo,1 Zhenhua Wu,1 David M. Holtzman,2 and Berislav V. Zlokovic1 1Frank P. Smith Laboratories for Neuroscience and Neurosurgical Research, Department of Neurosurgery and Division of Neurovascular Biology, Arthur Kornberg Medical Research Building, University of Rochester Medical Center, Rochester, New York 14642...
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ژورنال
عنوان ژورنال: CNS & Neurological Disorders - Drug Targets
سال: 2009
ISSN: 1871-5273
DOI: 10.2174/187152709787601867